Leigh syndrome – where are those mitochondria replacement therapies?

Dear Sir: I came across your blog after reading Stanley Bing’s recent article in Fortune Magazine. I will try to be brief. I have a 4 year old son who was diagnosed 1.5 years ago with a form of Leigh’s disease; one of the most devastating forms of mitochondrial disease. While he is receiving care… Continue reading Leigh syndrome – where are those mitochondria replacement therapies?

Nature Editor-in-Chief’s changed mind on enhancement drugs for healthy people

Philip Campbell, the open editor-in-chief of Nature was asked by John Brockman under the cover of the 2008 Edge Annual Question: WHAT HAVE YOU CHANGED YOUR MIND ABOUT? WHY? Campbell writes in his thoughtful answer: “I’ve changed my mind about the use of enhancement drugs by healthy people. A year ago, if asked, I’d have… Continue reading Nature Editor-in-Chief’s changed mind on enhancement drugs for healthy people

Bill Dye’s hope for an early regenerative medicine therapy! Please help.

Bill Dye has a serious muscle-tendon damage and is looking for an experimental regenerative medicine therapy (stem cells or tissue engineering or both) after 2 years and many surgical interventions. If any out of the expert readers of this blog can help or knows someone, who can help, please do comment or email Mr. Bill… Continue reading Bill Dye’s hope for an early regenerative medicine therapy! Please help.

Off-the-shelf skin replacements are on their way…

UK scientists in artificial skin breakthrough: “A long-lasting artificial skin has been developed by British researchers. The Cambridge-based Intercytex Group Plc has announced that tests had produced promising results in healing wounds in early clinical trials…. ICX-SKN is created from a matrix produced by the same skin cells that are responsible for synthesising new tissue… Continue reading Off-the-shelf skin replacements are on their way…

Bell curve in medical care: Atul Gawande in Author@Google

The Anna of my life mailed me the link of The Authors@Google program, which “brings authors of all stripes to Google for informal talks centering on their recently published books.” You can browse the Google Talks videos with one click. And non other than Atul Gawande, author of New Yorker’s opinionated The Way We Age… Continue reading Bell curve in medical care: Atul Gawande in Author@Google

Volunteers needed for amniotic stem cell transplantation onto ocular surfaces!

Would you like to have some human amniotic stem cells transplanted into your eye? Well, regenerative medicine wants you to participate in a pioneer study! If you are 18 – 88 year old, female and you have corneal epithelial defects and ulcers that have persisted for 4 weeks or longer but otherwise you are healthy,… Continue reading Volunteers needed for amniotic stem cell transplantation onto ocular surfaces!

Cord blood stem cell therapy without immune suppression?

The first scientific review of the rationale for the practical use of umbilical cord stem cells without the use of immune suppression was published in the Journal of Translational Medicine and it is freely available: “the authors propose that expanding the use of cord blood to non-preconditioned adult recipients for regenerative purposes would be a… Continue reading Cord blood stem cell therapy without immune suppression?

Disruptor candidate stem cell therapies

Stem cell therapies are likely to be disruptive treatments for the following medical sectors according to the Stem Cell Market Analysis Fact Sheet: What is interesting in the following list: all the target tissues are of mesodermal origin. • Total knee implants: Stem cell therapies that repair worn articular or meniscus cartilage will delay and… Continue reading Disruptor candidate stem cell therapies

Virgin’s Branson and stem cell banking

BBC News: “Virgin founder Richard Branson is set to launch a company which will let families bank and store stem cells from their child’s umbilical cord.” Question: Why just umbilical cord blood cells, why not amniotic fluid derived stem cells, or amniotic placental stem cells which have a far more wider regenerative potential than cord… Continue reading Virgin’s Branson and stem cell banking

Redifferentiating brain tumour stem cells: the concept of cancer regenerative medicine

The trendy cancer stem cell theory highlights that there is a functional hierarchy between different tumour cells and only a small portion, the so called cancer stem cells have crucial role in initiating tumour growth. This assumption was confirmed in the case of blood, breast and brain for example. Based on that a new therapeutic… Continue reading Redifferentiating brain tumour stem cells: the concept of cancer regenerative medicine

Real arguments not just echo chambering in embryonic stem cell funding debate

Finally a journalist at Wired, Brandon Keim thought it’s time to check out some facts and formulate real arguments in the embryonic stem cell funding debate instead of boondoggling. He has collected good historical examples of long-term funding in drug research, which then saved many lives, like Taxol, and has enumerated fields of promising science,… Continue reading Real arguments not just echo chambering in embryonic stem cell funding debate

Questions to contra life extensionists: rational pitfalls

Critical thinking is crucial to every successful scientific and technological project. In order to consider any attempt to the extension of life in details,we have to take a look at the other side of the coin. So in the future I try to blogterview some experts, scholars, philosophers, activists, …who are opposing some concrete points… Continue reading Questions to contra life extensionists: rational pitfalls

Maximum Life CEO David Kekich: the investment strategy of life extension

David A Kekich is a heavyweight venture capitalist and investment expert. In 1999, he founded the Maximum Life Foundation, a corporation dedicated to curing aging related diseases. His LIVES™ financial strategy will finance the research needed to profitably develop life extending technologies. Kekich, who is also a lifestyle life extensionist, and very aware of current… Continue reading Maximum Life CEO David Kekich: the investment strategy of life extension

FDA Stem Cell Therapy Regulation: the Framework

Dina Gould Halme and David A. Kessler wrote an article, called FDA Regulation of Stem-Cell–Based Therapies in The New England Journal of Medicine. The key concerns are: i., Stem-cell–based products as therapeutic agents are or could be: biologic products, drugs, devices, xenotransplantation products, human cells, tissues, and cellular and tissue-based products. Human cells, tissues, and… Continue reading FDA Stem Cell Therapy Regulation: the Framework

U.S. stem cell companies: a new roundup

From Investor’s Business Daily: Big pharmaceutical firms and major biotechs are holding back as well, William Caldwell CEO of Advanced Cell Technology says. “While all of them have stem cell development labs someplace in the bowels of their organizations, they are not putting capital into the sector.” These companies are nervous about the political and… Continue reading U.S. stem cell companies: a new roundup

$16Million Israeli fund for anti leukemia treatment StemEx

$16-million round of financing goes for Gamida Cell to bring StemEx, a treatment for leukemia and lymphoma to the market. From Red Herring: The funds will be used to expand the Israeli stem cell startup’s pipeline and bring products to market. …The company reported extremely favorable clinical results from phase I and II studies of… Continue reading $16Million Israeli fund for anti leukemia treatment StemEx

Rumors on Amatokin: a skin stem cell wrinkle cream?

Is Amatokin the first product to harness the potential of your own stem cells to reduce serious wrinkles? From Businesswire: This “super-secret” wrinkle cream, called Amatokin, is not really a cream at all, but a “highly efficient ‘barrier-neutral’ emulsion” containing a unique polypeptide compound (known in official circles as polypeptide #153). This meta-peptide was developed… Continue reading Rumors on Amatokin: a skin stem cell wrinkle cream?

Patent trends in recent tissue engineering

In Nature Biotechnology 24, 1095 (2006) there is an interesting table made by Thomson Scientific Search Service about recent patent applications in tissue engineering. From that we can gain a picture of what is hot in current tissue engineering: popular organs, tissues, regeneration targets are skin, bone, cartilage, main problem is how to make 3D… Continue reading Patent trends in recent tissue engineering

Stem cell therapy in Eastern Europe: the brute force method

Last week I was told by a man an interesting and weird story about his stem cell transplantation therapy somewhere in Eastern Europe. The elderly man was diagnosed with a motor neuron disease previous year which presently turned out to be amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease, the same that attacked Stephen Hawking… Continue reading Stem cell therapy in Eastern Europe: the brute force method