The Institute for the Future‘s X2 project is all about tracing future trends in science and technology As the steward of the Biomedical Sciences and Biotechnology Group I collect signals in these fields on which some forecasts can be based later on. Here are some issues I found future sensitive enough recently: GlaxoSmithKline collaborates with… Continue reading Science X2 signals: big pharmas, stem cells, mobile MRI
Finally Chris over at Ouroboros came up with the idea and the quick implementation of Hourglass, a blog carnival devoted to the biology of aging/biogerontology. For some reason I am not an explicit supporter of blog carnivals – many of my posts were chosen by carnival editors but I never hosted one -, but Hourglass… Continue reading Hourglass, a blog carnival devoted to the biology of aging
The concept of decellularizing complex organs in cadavers and reseeding the remaining matrix structure with differentiated, stem or progenitor cells, growing in a bioreactor and transplanting back to the organism could turn out to be a real technological shortcut in the field of tissue engineering. It is not a brand new story on the web,… Continue reading The decellularized matrix hack: skipping many steps in tissue engineering
The “Understanding Aging: Biomedical and Bioengineering Approaches” conference will be held from June 27-29, 2008 at UCLA organized by Aubrey de Grey, Irina Conboy and Amy Wagers. I like to call it UndertsEnding Aging in myself and I am excited to go to LA and meet new people also people from SENS3. Yesterday I created… Continue reading Understanding Aging Conference on FriendFeed!
Monya Baker has an excellent Q&A with the authors of the recent Nature Insight: Regenerative Medicine over at The Niche blog. Ken Chien, the author of Regenerative medicine and human models of human disease – see earlier post – recalls the paradigmatic story of heart transplantation and the 2 main surgeons behind, Norman Shumway and… Continue reading What path would you follow: Shumway or Barnard?
As far as I understand synthetic morphology = develompental biology +synthetic biology + tissue engineering + anatomy to create new cellular patterns. Jamie A. Davies: Synthetic morphology: prospects for engineered, self-constructing anatomies “This paper outlines prospects for applying the emerging techniques of synthetic biology to the field of anatomy, with the aim of programming cells… Continue reading Synthetic morphology: what kind of animal is that?
Finally I started to digest all the articles (usually on the streetcar on my way to work and home) from the recent Nature Insight: Regenerative Medicine and I try to pick up some stories for you (& interesting enough for me) from that, in case you are not lucky enough to have an available copy.… Continue reading Problem: embryonic stem cell lines vary & iPS lines too
The 2006 Nature Insight: Stem Cells edited by Nature Report Stem Cells editor Natalie DeWitt is still a basic reading for me. The newest Nature is accompanied by a similar supplement called Nature Insight: Regenerative Medicine
In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential. 1.2. Tissues, organs with different turnover and regenerative potential /bioenergetics data missing/ Liver… Continue reading Thesis live: 1.2 Liver, regeneration and stem/progenitor cells
In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential. 1.1 Stem cells and regenerative medicine The concept of the stem cell niche… Continue reading Thesis live 1.1 The stem cell niche
In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential. When producing a text, a post my building strategy is not linear, but… Continue reading Thesis live: 1.2 tissue/stem cell introduction scheme
In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential. After the Introduction draft it’s time to actually start to fill in the… Continue reading Thesis live: 1.1 Basic concepts: Let’s roll!
Did you know that physiological normoxia generally falls in the 2-9% O2 (14.4-64.8 mm Hg) range for most adult cells in vivo? 3 remarkable exceptions are thymus, kidney medulla and most importantly bone marrow which can exist at 1% O2 (7.2 mm Hg). On the other hand, stem and progenitor cells are frequent residents of… Continue reading Oxygen control of stem cell niches and cell fates
It’s Friday, that is a lunch heaven for a Gumbo loving biogeek at Tulane: Stem Cell Express: Copy Number Variant Analysis of Human Embryonic Stem Cells from the Teitell Lab (It’s good to see that CIRM funded results and papers are coming out):
From now on I start every “thesis live” post with the standard introduction: In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential… Continue reading Thesis live: Introduction, “contents” draft
Huffington Post, Fortune’s Stanley Bing: The Next Big Thing? Please pay extra attention to the language here (especially transmogrification). Human genome schmutz: Nobody wants to get old or worse, appear old. And forget about dying. That’s the ultimate bummer. Genetic research has been held back recently by a series of disasters too terrible to mention… Continue reading Very well informed Stanley Bing on life extension
I’ve just noticed a New York Times paid “stem cell research” Google Adwords ad in my gmail inbox besides the automated “Rejuvenation Research Vol. 11, No. 1, Feb 2008 is now available online” mail. That said, The New York Times is ranking the “stem cell” buzzword high and fishes for layman readers interested in the… Continue reading The New York Times advertises itself with stem cell research
This is exactly the type of clinical trial news that should be taken extremely carefully with all due respect and grief. A girl enrolled in a stem-cell trial for a fatal disease has died. In January, the nine-year-old received a brain transplant of neural stem cells derived from fetal tissue. She was one of six… Continue reading 9 year old stem cell trial pioneer dies in Batten disease
The successful reprogramming (dedifferentiation) of differentiated human somatic cells into a pluripotent, embryonic stem cell-like state called induced pluripotent stem cells (iPS) using just 4 (and recently 3) introduced transcription factors is the biggest news of current stem cell biology. In the paper published in Cell by the Yamanaka group (Takahashi et al.) the iPS… Continue reading induced Pluripotent Stem cells from a 69 year old human: the hidden story?
One strategy (call it Life Extension Gets Personal) to raise awareness for the idea and technology of healthy life extension is to publicly encourage life extension “coming outs” on behalf of mainstream celebrities. In order to get an academic legitimacy for LE (which is one of the most important aim of Pimm) I am interested… Continue reading Craig Venter and the life extension drive: blogterview questions
At least I know how to start my stem cell comprehensive exam tomorrow (The trick is to use blastocyst medium supplemented with laminin and fibronectin): Human Embryonic Stem Cell Lines Generated without Embryo Destruction Young Chung, Irina Klimanskaya, Sandy Becker, Tong Li, Marc Maserati, Shi-Jiang Lu, Tamara Zdravkovic, Dusko Ilic, Olga Genbacev, Susan Fisher, Ana… Continue reading Out of 8 embryo cells: if 1 turned to an ES cell, 7 could still become a child
Different attitudes, same endeavors. 1. The folks at the California Institute of Regenerative Medicine (CIRM) started to offer grants for biotech companies up to $55,000 out of the 3 billion ‘hope’ dollars. San Diego Union Tribune: Industry and academia team up: For the first time in its three-year existence, the state taxpayer-funded stem cell institute… Continue reading CIRM and NIH stem cell grants to the biotech industry
According to the newest Request For Applications (RFA) of the California Institute for Regenerative Medicine (CIRM), the New Cell Line Awards will support two categories of research: Category 1: Derivation of new hESC lines using excess or rejected early stage human embryos generated by in vitro fertilization. Category 2: Derivation of pluripotent human stem cell… Continue reading California embryonic stem cell dollars: beyond the embryonic phase
Stem cell biology – regenerative medicine 1. basic concepts: stem cell, kinds of stem cells (embryonic, placental, adult), uni-, multi-, pluripotency, stem cell markers, niche, regeneration, tissue engineering
Jon Rowley is a senior manager at Aastrom Biosciences with a long experience in the not too old Regenerative Medicine field. I am pleased to introduce here his new blog The Regeneration Station as one of the first biotech – regmed blog written by an industrial expert who will share with us his insights on… Continue reading The Regeneration Station – a biotech blog by Aastrom’s Jon Rowley
Once I wrote shortly about the following peer review paper which was popped out of my PubMed feeds to draw some attention to it: Han Qin, Tianxin Yu, Tingting Qing, Yanxia Liu, Yang Zhao, Jun Cai, Jian Li, Zhihua Song, Xiuxia Qu, Peng Zhou, Jiong Wu, Mingxiao Ding, Hongkui Deng Regulation of apoptosis and differentiation… Continue reading Unofficial and hypercritical peer review of a paper on p53’s role in hESC regulation
It is a somewhat very positive idea that human tissues previously considered as waste products (after filling their essential role in the human body) like the placenta and the umbilical cord are radically reinterpreted as valuable sources of prospective therapies due to the current results of stem cell research and regenerative medicine. Exactly this reinterpretation… Continue reading Collect and FedEx menstrual stem cells with the C’elle kit: the next flow
Did you now what oracy means? Never mind. From late September, Oracy is the blog of Tulane grad student and colleague Gregory Block, whom you can catch now just in the middle of finding his blog voice. Topics are focused on rants about science (specially stem cells), Greg’s melancholy music and stories from New Orleans.… Continue reading Greg Block’s Oracy and science as an exercise in humanitarianism
If you ever thought of launching a biotech startup… the following blogterview is for you. Jim Hardy is a long time insighful commenter of Pimm and he shared with me his brand new experience as the founder of a biotech startup in the much hyped field of regenerative medicine. The transparency of the interview makes… Continue reading The busy life of a stem cell (biotech) startup founder
Honestly, there are not too many good, stem cell related blogs out there. By “good stem cell blogs” I mean blogs that are regularly updated in a niche stem cell related field full with quality science information followed by original opinions and ideas and not just human or algorithmic link blogs. Here are 3 solid… Continue reading Where are the quality stem cell blogs?
Robert Lanza is now the Chief Scientific Officer of Advanced Cell Technology, while Michael West is voluntarily stepping down as the company’s President and Chief Scientific Officer and jumps into the CEO seat of BioTime Inc.. Lanza and West are 2 legendary figures in the biotech industry, and here are 2 interesting things concerning them:… Continue reading Lanza up, West down at Advanced Cell Technology
Recently I wrote a meeting report on the SENS3 conference for a very prestigious science journal, but finally it did not go through the filters. I knew that the chance for publication is small as the journal rarely publish such meeting reports and as it was in many respects an unconventional science conference. The standards… Continue reading Unpublished SENS3 conference report for mainstream scientists!
The Nobel Assembly at Karolinska Institute has today decided to award The Nobel Prize in Physiology or Medicine for 2007 jointly to Mario R. Capecchi, Martin J. Evans and Oliver Smithies for their discoveries of “principles for introducing specific gene modifications in mice by the use of embryonic stem cells” Link It’s rather a 2/3… Continue reading The first stem cell related Nobel prize: Martin Evans, 2007
It is now the 3rd issue of Cell Stem Cell, which is the official journal of the International Society for Stem Cell Research (ISSCR). From the current issue: In human pancreatic cancer a distinct subpopulation of migrating CD133+ CXCR4+ cancer stem cells turned out to be essential for tumor metastasis different from the ones responsible… Continue reading Biopolis profile and cancer stem cells in current Cell Stem Cell
In the unique state of California there is now an offer for individuals to place orders from October 3 during a $250 million sale of state debt to fund embryonic stem-cell research. The minimum bet is $5,000 and over 1 million you need special permission (just like buying more than 2 iPhones in the early… Continue reading United State of California: buy bonds in stem cell research
Let’s continue our Hit art illustrations for scientific slides project this time with van Gogh’s “Starry night“. The slide is from Chang-Kyu Lee’s presentation on the SENS3 conference, entitled Interspecies somatic cell nuclear transfer for establishing embryonic stem cells with desired genotype.
Linda Powers is the managing director and co-founder of Toucan Capital Corp, a $120 million venture capital fund (SBIC) focused on seed and early-stage life science and advanced technology investments (the fund markets itself as the The Leading US Investor in Stem Cells and Regenerative Medicine). Out of here insights and facts presented on the… Continue reading SENS3: The stem cell marketplace by Linda Powers, Tucan Capital (slides)
The immortal strand hypothesis captures stem cell scientists’ imagination these days. According to Thomas Rando The immortal strand hypothesis posits that the propensity of stem cell compartments to give rise to cancer in later life can be minimized if stem cells, during the process of self-renewal, retain those DNA strands with the fewest mutations acquired… Continue reading SENS3 program: Mike Conboy on the immortal strand hypothesis
Back in June I was a happy beta tester of Nature Precedings, Nature’s own free preprint server. I uploaded a poster of our group called Intact mitochondria migrate in membrane tubular network connections formed between human stem cells by Csordas, Attila, Cselenyák, Attila, Uher, Ferenc, Murányi, Marianna, Hennerbichler, Simone, Redl, Heinz, Kollai, Márk, and Lacza,… Continue reading Mitochondria in the tubes of stem cells poster on Nature Precedings
I am visiting the third Strategies for Engineered Negligible Senescence (SENS3) conference, which will be held from 6-10 September 2007 at Queens’ College, Cambridge. Aubrey de Grey (with whom I made a blogterview in 2006), the main organizer and soul behind the conference is clear about the purpose: “The purpose of the SENS conference series,… Continue reading Going to another unconventional science meeting: SENS3, Cambridge, UK