The Institute for the Future‘s X2 project is all about tracing future trends in science and technology As the steward of the Biomedical Sciences and Biotechnology Group I collect signals in these fields on which some forecasts can be based later on. Here are some issues I found future sensitive enough recently: GlaxoSmithKline collaborates with… Continue reading Science X2 signals: big pharmas, stem cells, mobile MRI
Last year I was probably the only SciFoo Camper with an explicit life extension commitment. I suggested & held a session which was related a bit to partial immortalization but was rather about the systems biology perspective in general, illustrated with some examples. So throughout the terrific SciFoo Camp 2007 life extension as a conversation… Continue reading Life extension people & session at SciFoo 2008, Googleplex!
Finally Chris over at Ouroboros came up with the idea and the quick implementation of Hourglass, a blog carnival devoted to the biology of aging/biogerontology. For some reason I am not an explicit supporter of blog carnivals – many of my posts were chosen by carnival editors but I never hosted one -, but Hourglass… Continue reading Hourglass, a blog carnival devoted to the biology of aging
The concept of decellularizing complex organs in cadavers and reseeding the remaining matrix structure with differentiated, stem or progenitor cells, growing in a bioreactor and transplanting back to the organism could turn out to be a real technological shortcut in the field of tissue engineering. It is not a brand new story on the web,… Continue reading The decellularized matrix hack: skipping many steps in tissue engineering
The “Understanding Aging: Biomedical and Bioengineering Approaches” conference will be held from June 27-29, 2008 at UCLA organized by Aubrey de Grey, Irina Conboy and Amy Wagers. I like to call it UndertsEnding Aging in myself and I am excited to go to LA and meet new people also people from SENS3. Yesterday I created… Continue reading Understanding Aging Conference on FriendFeed!
Finally I started to digest all the articles (usually on the streetcar on my way to work and home) from the recent Nature Insight: Regenerative Medicine and I try to pick up some stories for you (& interesting enough for me) from that, in case you are not lucky enough to have an available copy.… Continue reading Problem: embryonic stem cell lines vary & iPS lines too
The 2006 Nature Insight: Stem Cells edited by Nature Report Stem Cells editor Natalie DeWitt is still a basic reading for me. The newest Nature is accompanied by a similar supplement called Nature Insight: Regenerative Medicine
In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential. 1.2. Tissues, organs with different turnover and regenerative potential /bioenergetics data missing/ Liver… Continue reading Thesis live: 1.2 Liver, regeneration and stem/progenitor cells
In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential. 1.1 Stem cells and regenerative medicine The concept of the stem cell niche… Continue reading Thesis live 1.1 The stem cell niche
In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential. When producing a text, a post my building strategy is not linear, but… Continue reading Thesis live: 1.2 tissue/stem cell introduction scheme
In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential. After the Introduction draft it’s time to actually start to fill in the… Continue reading Thesis live: 1.1 Basic concepts: Let’s roll!
It’s Friday, that is a lunch heaven for a Gumbo loving biogeek at Tulane: Stem Cell Express: Copy Number Variant Analysis of Human Embryonic Stem Cells from the Teitell Lab (It’s good to see that CIRM funded results and papers are coming out):
From now on I start every “thesis live” post with the standard introduction: In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential… Continue reading Thesis live: Introduction, “contents” draft
Press release: “We at Life Extension Foundation are pleased to help finance BioTime‘s entry into the field of regenerative medicine. We believe that one of the most important applications of embryonic stem cell technology is the slowing and reversing of aging and age-related disease.
Looks like the scientist coalition behind healthy life extension is widening. In line with that the question Why was life extension ruled out of the 14 Grand Engineering Challenges? is fading away. Here is an Aubrey de Grey message from my mailbox: All details, including forms for abstract submission and online registration, are at the… Continue reading Understanding Aging Conference in L.A.: de Grey, Conboy, Wagers and many others…
I’ve just noticed a New York Times paid “stem cell research” Google Adwords ad in my gmail inbox besides the automated “Rejuvenation Research Vol. 11, No. 1, Feb 2008 is now available online” mail. That said, The New York Times is ranking the “stem cell” buzzword high and fishes for layman readers interested in the… Continue reading The New York Times advertises itself with stem cell research
…that can be realistically met, most of them early in this century according to the Committee on Grand Challenges for Engineering with members such as Larry Page, Dean Kamen, Craig Venter, Robert Langer and …lifestyle life extensionist, nanovisionary Ray Kurzweil. There is a challenge though called Engineer better medicines and the essay behind looks as… Continue reading Healthy life extension is not 1 out of the 14 Grand Engineering Challenges…
This is exactly the type of clinical trial news that should be taken extremely carefully with all due respect and grief. A girl enrolled in a stem-cell trial for a fatal disease has died. In January, the nine-year-old received a brain transplant of neural stem cells derived from fetal tissue. She was one of six… Continue reading 9 year old stem cell trial pioneer dies in Batten disease
The successful reprogramming (dedifferentiation) of differentiated human somatic cells into a pluripotent, embryonic stem cell-like state called induced pluripotent stem cells (iPS) using just 4 (and recently 3) introduced transcription factors is the biggest news of current stem cell biology. In the paper published in Cell by the Yamanaka group (Takahashi et al.) the iPS… Continue reading induced Pluripotent Stem cells from a 69 year old human: the hidden story?
One strategy (call it Life Extension Gets Personal) to raise awareness for the idea and technology of healthy life extension is to publicly encourage life extension “coming outs” on behalf of mainstream celebrities. In order to get an academic legitimacy for LE (which is one of the most important aim of Pimm) I am interested… Continue reading Craig Venter and the life extension drive: blogterview questions
Biotech entrepreneurs and wantrepreneurs, here is a tip for Ya to launch a regmed business (and don’t forget to market the product as recycled and green) : Winston-Salem Journal: Human hair could hold key to regeneration of nerve tissue, Wake Forest research shows The study, published in the current issue of Biomaterials, found that the… Continue reading Startup recipe: collect hair at the barber, isolate keratin, regenerate nerves
Different attitudes, same endeavors. 1. The folks at the California Institute of Regenerative Medicine (CIRM) started to offer grants for biotech companies up to $55,000 out of the 3 billion ‘hope’ dollars. San Diego Union Tribune: Industry and academia team up: For the first time in its three-year existence, the state taxpayer-funded stem cell institute… Continue reading CIRM and NIH stem cell grants to the biotech industry
The Economist print edition (Jan 3rd) has a summary article on the current healthy and scientific life extension scene starting with Aubrey De Grey’s engineering, umbrella SENS approach and talking about anti-oxidants, mitochondria, sirtuin activators and stem cell based regenerative medicine amongst others. To my positive surprise the unknown writer of the article (do you… Continue reading Partial immortalisation goes mainstream with an ‘s’ – thanks to the Economist!
According to the newest Request For Applications (RFA) of the California Institute for Regenerative Medicine (CIRM), the New Cell Line Awards will support two categories of research: Category 1: Derivation of new hESC lines using excess or rejected early stage human embryos generated by in vitro fertilization. Category 2: Derivation of pluripotent human stem cell… Continue reading California embryonic stem cell dollars: beyond the embryonic phase
Stem cell biology – regenerative medicine 1. basic concepts: stem cell, kinds of stem cells (embryonic, placental, adult), uni-, multi-, pluripotency, stem cell markers, niche, regeneration, tissue engineering
Jon Rowley is a senior manager at Aastrom Biosciences with a long experience in the not too old Regenerative Medicine field. I am pleased to introduce here his new blog The Regeneration Station as one of the first biotech – regmed blog written by an industrial expert who will share with us his insights on… Continue reading The Regeneration Station – a biotech blog by Aastrom’s Jon Rowley
It is a somewhat very positive idea that human tissues previously considered as waste products (after filling their essential role in the human body) like the placenta and the umbilical cord are radically reinterpreted as valuable sources of prospective therapies due to the current results of stem cell research and regenerative medicine. Exactly this reinterpretation… Continue reading Collect and FedEx menstrual stem cells with the C’elle kit: the next flow
If you ever thought of launching a biotech startup… the following blogterview is for you. Jim Hardy is a long time insighful commenter of Pimm and he shared with me his brand new experience as the founder of a biotech startup in the much hyped field of regenerative medicine. The transparency of the interview makes… Continue reading The busy life of a stem cell (biotech) startup founder
Honestly, there are not too many good, stem cell related blogs out there. By “good stem cell blogs” I mean blogs that are regularly updated in a niche stem cell related field full with quality science information followed by original opinions and ideas and not just human or algorithmic link blogs. Here are 3 solid… Continue reading Where are the quality stem cell blogs?
Robert Lanza is now the Chief Scientific Officer of Advanced Cell Technology, while Michael West is voluntarily stepping down as the company’s President and Chief Scientific Officer and jumps into the CEO seat of BioTime Inc.. Lanza and West are 2 legendary figures in the biotech industry, and here are 2 interesting things concerning them:… Continue reading Lanza up, West down at Advanced Cell Technology
Bill Dye has a serious muscle-tendon damage and is looking for an experimental regenerative medicine therapy (stem cells or tissue engineering or both) after 2 years and many surgical interventions. If any out of the expert readers of this blog can help or knows someone, who can help, please do comment or email Mr. Bill… Continue reading Bill Dye’s hope for an early regenerative medicine therapy! Please help.
It is now the 3rd issue of Cell Stem Cell, which is the official journal of the International Society for Stem Cell Research (ISSCR). From the current issue: In human pancreatic cancer a distinct subpopulation of migrating CD133+ CXCR4+ cancer stem cells turned out to be essential for tumor metastasis different from the ones responsible… Continue reading Biopolis profile and cancer stem cells in current Cell Stem Cell
In the unique state of California there is now an offer for individuals to place orders from October 3 during a $250 million sale of state debt to fund embryonic stem-cell research. The minimum bet is $5,000 and over 1 million you need special permission (just like buying more than 2 iPhones in the early… Continue reading United State of California: buy bonds in stem cell research
It’s Friday so the web is going to sleep for the weekend, but here is one more opinion on life extension, in this case the opinion of Arthur Caplan chair of the Department of Medical Ethics and director of the Center for Bioethics at the University of Pennsylvania, and columnist on bioethics for MSNBC: Source:… Continue reading Biomedical life extension is the next big battleground, Caplan says
Linda Powers is the managing director and co-founder of Toucan Capital Corp, a $120 million venture capital fund (SBIC) focused on seed and early-stage life science and advanced technology investments (the fund markets itself as the The Leading US Investor in Stem Cells and Regenerative Medicine). Out of here insights and facts presented on the… Continue reading SENS3: The stem cell marketplace by Linda Powers, Tucan Capital (slides)
The immortal strand hypothesis captures stem cell scientists’ imagination these days. According to Thomas Rando The immortal strand hypothesis posits that the propensity of stem cell compartments to give rise to cancer in later life can be minimized if stem cells, during the process of self-renewal, retain those DNA strands with the fewest mutations acquired… Continue reading SENS3 program: Mike Conboy on the immortal strand hypothesis
Help me to collect the list of art illustrations that are frequently used and overused by scientists on their slides either as background or as an analogy for some biological or other scientific phenomenon! The first one is the “Fons Juventutis” (“Fountain of Youth“) and now quickly switch to wikipedian composed by Cranach, executed by… Continue reading Hit art illustrations for scientific slides: Fountain of youth by Cranach
Embedded is my classical style (no design, based on the figure section, Powerpoint instead of Keynote) Journal Club presentation on the following paper with the help of SlideShare: Alteration of Marrow Cell Gene Expression, Protein Production and Engraftment into Lung by Lung-derived Microvesicles: A Novel Mechanism for Phenotype Modulation by Aliotta JM, Sanchez-Guijo FM, Dooner… Continue reading Journal Club slideshow: MSC lung repair via lung-derived microvesicles
Maxine Clarke over at Nature’s Nautilus blog published Nature’s July top ten PDF downloads. July was a particularly strong month for Nature concerning pluripotency and embryonic stem cells as 5 out of the 10 top ten downloads, that is 50% of the most popular articles are tinkering with stem cell biology. The other trend: microRNAs,… Continue reading Trends in Nature’s July top ten PDF downloads: 5 stem cell papers!
There are way too much papers and data published in the field of stem cell biology and regenerative medicine to follow and filter with traditional offline, spread of mouth tools. At the Journal Club section of Nature Reports Stem Cells, researchers have the opportunity to highlight and discuss the papers they found of utmost importance… Continue reading Make a pro buzz for your favourite stem cell papers at Nature Reports Stem Cells!