Continuous lifespan extension as a coherent life plan enables super-agency

Introduction In ‘Agency, Life Extension, and the Meaning of Life‘, professional philosopher Lisa Bortolotti argues that the so-called agency objection against a loosely defined life extension technology should be rejected. Briefly put, the agency objection argues that one important component of the meaningfulness of human life is being constrained as an agent and since ‘life extension’… Continue reading Continuous lifespan extension as a coherent life plan enables super-agency

Robust lifespan extension & ecological awareness: can an exponentially extended human life be a hyperobject?

Warning: this post is only ~30% complete, the rest will be added in case of further interest from you. Hope I can incorporate comments from other humans to give a much better formulation. I am making myself intentionally vulnerable here wanting to engage in a conversation. Imagine the following: you are living potentially not up… Continue reading Robust lifespan extension & ecological awareness: can an exponentially extended human life be a hyperobject?

AgeCurve Limited and Gen P: my business angle on aging and longevity

After 20 something years of living a diverse educational and professional life motivated by healthy lifespan extension and dominated by science and technology I have reached the riskiest and most rewarding phase: launching a business around it and making it real. I have founded a startup, called AgeCurve Limited and we are already offering a product,… Continue reading AgeCurve Limited and Gen P: my business angle on aging and longevity

1 day Apache Spark training: randomish insights

Last week I’ve participated in a one day Apache Spark workshop in London developed by Databricks and organised by Big Data Partnership. Databricks Training Resources is the most important link you need to know in order to get started, contains the whole training material. Let me share some short comments: Spark is the next, logical generalised step leveraging the… Continue reading 1 day Apache Spark training: randomish insights

Big list of Markov chain Monte Carlo (MCMC) applications

I became quite obsessed with Markov chain Monte Carlo Methods lately. It is said that MCMC methods form the most frequently used class of algorithms in computer science. However when I was searching for a comprehensive list of MCMC applications across different domains to my surprise I have found none. So I’d like to ask… Continue reading Big list of Markov chain Monte Carlo (MCMC) applications

Hadoop 101 for bioinformaticians: 1 hour crash course, code and slides

Earlier this year (February-April) I ran 9 short 1 hour hands-on sessions (5 persons/session) called Hadoop 101 for bioinformaticians at the Genome Campus for European Bioinformatics Institute and Sanger Institute people. The participants were bioinformaticians, developers and sysadmins. My idea was to start with a ~20 minutes long theoretical introduction so it provides some handles on whether… Continue reading Hadoop 101 for bioinformaticians: 1 hour crash course, code and slides

Pleasingly Parallel MCMC: cracked wide open for MapReduce and Hadoop

MCMC methods guarantee an accurate enough result (say parameter estimation for a phylogenetic tree). But they give it to you usually in the long-run and many burn-in steps might be necessary before performing ok. And if the data size grows larger, the number of operations to draw a sample grows larger too (N -> O(N)… Continue reading Pleasingly Parallel MCMC: cracked wide open for MapReduce and Hadoop

2 recent Global Alliance for Genomics and Health standard candidates: ADAM and Google Genomics

Global Alliance for Genomics and Health includes > 150 health and research organizations to progress/accelerate secure and responsible sharing of genomic and clinical data. GA4GH (for short) is something you will here about more and more in the short term future. In the context of genomics standards think of mainly data formats and code to access and process… Continue reading 2 recent Global Alliance for Genomics and Health standard candidates: ADAM and Google Genomics

3 recent Hadoop/MapReduce applications in the life sciences: RNA structure prediction, neuroimaging genetics, EEG signal analysis

3 open access papers, 3 prototypes, source code available only for 1, healthy diversification of topics. 1. Enhancement of accuracy and efficiency for RNA secondary structure prediction by sequence segmentation and MapReduce code available: haven’t found it referenced in the paper Our previous research shows that cutting long sequences into shorter chunks, predicting secondary structures of… Continue reading 3 recent Hadoop/MapReduce applications in the life sciences: RNA structure prediction, neuroimaging genetics, EEG signal analysis

Google invests into DNAnexus: aging-driven big data bioinformatics without the Hadoop Ecosystem?

First time DNAnexus made me think a little about what they can achieve was when they came up with an alternative search and browse interface for the complete Sequence Read Archive (SRA) database. They came to the ‘rescue’ as NCBI discontinued SRA in 2011 although later they’ve changed their mind, so SRA is still up and running there.… Continue reading Google invests into DNAnexus: aging-driven big data bioinformatics without the Hadoop Ecosystem?

Coming of age for proteogenomics: 10% less human protein coding genes based on mass spec proteomics data?

Guessing the number of real protein-coding genes is an ‘ancient’ bioinformatics game and now a new argument & newish research field has been applied to this problem. Proteogenomics can refer to different type of studies but the basic idea is that mass spectrometry peptide/protein evidences are used to improve genome annotations. Now a joint Spanish –… Continue reading Coming of age for proteogenomics: 10% less human protein coding genes based on mass spec proteomics data?

Three links in Aging, Regenerative Medicine & Healthy Lifespan Extension: 17 December 2013

1. DNA methylation age of human tissues and cell types by Steve Horvath: This is the type of relevant data mining study most bioinformaticians are dreaming of: you pull together a large body of publicly available datasets (CpG methylation) that are not too heterogeneous (Infinium type II assay on Illumina 27K or Illumina 450K array platform), derive robust… Continue reading Three links in Aging, Regenerative Medicine & Healthy Lifespan Extension: 17 December 2013

Three links in Aging, Regenerative Medicine & Healthy Lifespan Extension: 24 November 2013

Introducing a new post format by reutilising Nat Torkington’s Four short links format over at O’Reilly Radar (thanks, Nat!).   1.  The Hallmarks of Aging: good review by European scientists trying to put some pieces next to each other (but not necessarily together). The 9 hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis,… Continue reading Three links in Aging, Regenerative Medicine & Healthy Lifespan Extension: 24 November 2013

How to build a colorful life around life extension using different skills: a personal story

Here’s an edited version of my Quora answer to the question: “Life Decisions: How do people who are talented in many areas decide what to do with their lives?“ Let me provide a personal story illuminating one option Ruchira is talking about: “pick a complex challenge that you are passionate about, that will require many different… Continue reading How to build a colorful life around life extension using different skills: a personal story

Google Health, IBM: real-time, vital medical data stream

Forbes article: Letting Google Take Your Pulse via @mattcutts: On Thursday, Google and IBM will unveil a new initiative that will allow Google Health, a site where users can store and track information about their medical history, to connect to and stream data from medical devices. In demonstrations, IBM and Google fitted Wi-Fi radios to… Continue reading Google Health, IBM: real-time, vital medical data stream

Are life extensionists mainly driven by a desire to actually live a long time?

How do you interpret the following situation: we have a life extension technologist whose all endeavors is about pushing this issue to its very limits and making things possible but on the other hand this very life extensionist himself is not driven by actually living as long as he can. It seems that SENS theorist… Continue reading Are life extensionists mainly driven by a desire to actually live a long time?

“blogs.nature.com v1 is live” and beyond

A new, completely rewritten, integrated nature.com website blogs.nature.com has been launched by the Natureplex people – informed his Twitter pals Euan Adie: Also, blogs.nature.com v1 is live! Tequila and donuts all round. Early n’ often release v2 coming on the 18th so get any bug reports in now. Suggest good science blogs that are not… Continue reading “blogs.nature.com v1 is live” and beyond

Mountain View – Budapest: 20 days to get my 23andMe profile!

I ordered my first commercial genetic profile from 23andMe on the 9th of September online, FedExed my 2 ml saliva from Budapest to 23andMe, Mountain View on the 12th of September. I got the results today. That said within 3 weeks since the birth of the idea I purchased more than 500 000 SNPs of… Continue reading Mountain View – Budapest: 20 days to get my 23andMe profile!

Science X2 signals: big pharmas, stem cells, mobile MRI

The Institute for the Future‘s X2 project is all about tracing future trends in science and technology As the steward of the Biomedical Sciences and Biotechnology Group I collect signals in these fields on which some forecasts can be based later on. Here are some issues I found future sensitive enough recently: GlaxoSmithKline collaborates with… Continue reading Science X2 signals: big pharmas, stem cells, mobile MRI

Even ugly handwriting can fit the informal nature of SciFoo

I had problems with my handwriting since elementary schools, or at least my teachers had continuous problems with it. Even during my university years I was asked sometimes to read out loud my essays, papers to them otherwise risking bad grades. Maybe it’s because I am a hidden right-handed using my left hand for writing… Continue reading Even ugly handwriting can fit the informal nature of SciFoo

Sergey Brin, Gly2019Ser & a real chance against Parkinson disease/aging!

It was already known that amongst the Google top people Sergey Brin is the one who is most interested in pushing biotechnology and the biomedical sciences: in his Stanford years he was interested in biology courses according to The Google Story, he married Anne Wojcicki (who graduted from biology at Yale), Google invested $4.4 million… Continue reading Sergey Brin, Gly2019Ser & a real chance against Parkinson disease/aging!

My personalized genetics: 2 ml saliva FedExed to 23andMe!

As the second operation of building my genetically well informed future yesterday (2 days after completing the order) I collected 2 ml of my saliva with the help of 23andMe’s Oragene DNA self-collection kit manufactured by DNA Genotek. First operation has been the sequencing of the D-loop of my mitochondrial DNA out of 5 ml… Continue reading My personalized genetics: 2 ml saliva FedExed to 23andMe!

The marketing problem of life extension technologies

If “Science has a really serious marketing problem” as Larry Page observed, then life extension technologies face even bigger marketing problems. I am definitely not a marketing expert but realized the problem early on when thinking about the lag-phase period of a robust life extension technology.  So I made a short email interview with Dave… Continue reading The marketing problem of life extension technologies

Life extension people & session at SciFoo 2008, Googleplex!

Last year I was probably the only SciFoo Camper with an explicit life extension commitment. I suggested & held a session which was related a bit to partial immortalization but was rather about the systems biology perspective in general, illustrated with some examples. So throughout the terrific SciFoo Camp 2007 life extension as a conversation… Continue reading Life extension people & session at SciFoo 2008, Googleplex!

Hourglass, a blog carnival devoted to the biology of aging

Finally Chris over at Ouroboros came up with the idea and the quick implementation of Hourglass, a blog carnival devoted to the biology of aging/biogerontology.  For some reason I am not an explicit supporter of blog carnivals – many of my posts were chosen by carnival editors but I never hosted one -, but Hourglass… Continue reading Hourglass, a blog carnival devoted to the biology of aging

Understanding Aging Conference is over but it is the end of the beginning

I try to cover some interesting, sciencey points on the conference in later posts, right now just a brief, subjective human- and strategy focused summary: Congrats to Aubrey de Grey and the team, everything went well and if finally a worldwide consensus is around the corner claiming that robust healthy lifespan extension is technologically possible… Continue reading Understanding Aging Conference is over but it is the end of the beginning

Petabyte Age Wiredesque lesson on what science can learn from Google

I argued many times here that biology based biotechnology is the next information technology but in order to do so, biotech should harness good IT patterns and mimic its massive computing practices to handle the enormous amount of constantly accumulating data. Often this trend could be summarized in a simple way: keep your eye on… Continue reading Petabyte Age Wiredesque lesson on what science can learn from Google

Understanding Aging Conference on FriendFeed!

The “Understanding Aging: Biomedical and Bioengineering Approaches” conference will be held from June 27-29, 2008 at UCLA organized by Aubrey de Grey, Irina Conboy and Amy Wagers. I like to call it UndertsEnding Aging in myself and I am excited to go to LA and meet new people also people from SENS3. Yesterday I created… Continue reading Understanding Aging Conference on FriendFeed!

Short Twitter/FriendFeed chat on life extension

I asked the following question on Twitter recently: “A question for all of you Twitterers: Are you for, against, or just neutral on healthy life extension? How long would you like to live? Why?” I have to tell you it’s hard to give good links to the whole chat without noise. Maybe on FriendFeed. To… Continue reading Short Twitter/FriendFeed chat on life extension

Embedding the Future: the X2 Project goes public!

With the public launch of the X2 project, Alex Soojung-Kim Pang realized one of his dreams. Alex is the research director of The Institute for the Future (IFTF), an independent nonprofit research group headquartered in Palo Alto, Silicon Valley. He writes: The project is called X2, and its aim is to forecast the future of… Continue reading Embedding the Future: the X2 Project goes public!

BioBarCamp in the Valley before the SciFoo Camp!

It seems that my favorite ever unconference, the SciFoo Camp will be aroundunconferenced by a BioBarCamp this year. The whole idea of the BioBarCamp is based upon the SciFoo Camp, so it is by no means a competitive but a complimentary event. From the BarCamp wiki: “The BioBarCamp is an idea (fed by the tweets… Continue reading BioBarCamp in the Valley before the SciFoo Camp!

3rd SciFoo Camp, Googleplex, August 8-10, 2008!

The 3rd Science Foo Camp, organized by Nature, O’Reilly Media, and Google will be held on August 8-10 and hosted at the Googleplex in Mountain View, CA. From the mail: “Now in its third year, Sci Foo is already achieving cult status among those with a passion for science and technology. The Economist said that… Continue reading 3rd SciFoo Camp, Googleplex, August 8-10, 2008!

Human proteome project: 21000 genes/1 protein, 10 years, $1 billion?

In order to have the slightest change to design a robust, systemic life extension technology, we need to accumulate every systemic macromolecular, cellular, tissue- and organ level data of the normal, physiological human body, connect the trillions of nodes with scalable software algorithms and suck out the draft of the proper sequence of consecutive treatment/regeneration… Continue reading Human proteome project: 21000 genes/1 protein, 10 years, $1 billion?

Thesis live: 1.2 Kidney and stem cells

In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential. 1.2. Tissues, organs with different turnover and regenerative potential In the adult kidney… Continue reading Thesis live: 1.2 Kidney and stem cells