If you have previously thought (in your spare time) that the conventional wisdom concerning blood formation is that the yolk sac’s embryonic blood-forming cells serve only the embryo, while the source of adult blood-forming stem cells is the region called aorta-gonad-mesonephros (AGM), it’s time to think it again due the elegant experiments of Samokhalov et… Continue reading 2 models of embryonic and adult blood formation: Figure by Ueno and Weissman
Circulating bone marrow derived adult stem cells may serve as a backup rescue system if the pool of endogenous stem cells is exhausted (see cartoon). BM derived adult stem cells are the best characterized adult stem cells in humans (reviewed in Vieyra et al, 2005). The hematopoietic stem cell fraction of the bone marrow are… Continue reading Bone marrow derived adult stem cells: which way to go?
From Investor’s Business Daily: Big pharmaceutical firms and major biotechs are holding back as well, William Caldwell CEO of Advanced Cell Technology says. “While all of them have stem cell development labs someplace in the bowels of their organizations, they are not putting capital into the sector.” These companies are nervous about the political and… Continue reading U.S. stem cell companies: a new roundup
$16-million round of financing goes for Gamida Cell to bring StemEx, a treatment for leukemia and lymphoma to the market. From Red Herring: The funds will be used to expand the Israeli stem cell startup’s pipeline and bring products to market. …The company reported extremely favorable clinical results from phase I and II studies of… Continue reading $16Million Israeli fund for anti leukemia treatment StemEx
Latest PNAS Early article by Stanford and McMaster researchers about the regulatory role of Hedgehog (Hh) signaling pathway in the balance between hematopoietic stem cell (HSC) homeostasis and regeneration in vivo. In brief: continued Hh activation during regeneration leads to HSC exhaustion. Link.