The LavaAmp is a portable PCR thermocycler that has the potential to become the default garage biology (home biology, bioDIY, DIYbio) tool once it hits the market. Think of Apple II for personal computing or MakerBot for 3D printing. The 1st LavaAmp prototype was shipped this week from Biodesic to Gahaga Biosciences and the process… Continue reading LavaAmp: cheapest pocket PCR thermocycler dreamed for DIY biologists
It was already known that amongst the Google top people Sergey Brin is the one who is most interested in pushing biotechnology and the biomedical sciences: in his Stanford years he was interested in biology courses according to The Google Story, he married Anne Wojcicki (who graduted from biology at Yale), Google invested $4.4 million… Continue reading Sergey Brin, Gly2019Ser & a real chance against Parkinson disease/aging!
As the second operation of building my genetically well informed future yesterday (2 days after completing the order) I collected 2 ml of my saliva with the help of 23andMe’s Oragene DNA self-collection kit manufactured by DNA Genotek. First operation has been the sequencing of the D-loop of my mitochondrial DNA out of 5 ml… Continue reading My personalized genetics: 2 ml saliva FedExed to 23andMe!
Mason-Dixon line Left side: QIAamp DNA Mini Kit for 250 DNA preps ($556.00) for purification of genomic, mitochondrial, bacterial, parasite, or viral DNA Right side: RNeasy Mini Kit (50) for purification of up to 100 ug total RNA from animal cells or tissues, yeast, or bacteria ($227.00)
“We really think that we can change Health Care…I want to change it in 5 years…it has to change and that’s we all are about” – says Anne Wojcicki, 23andMe co-founder, in the Google Tech Talk on Googling the Googlers’ DNA: A Demonstration of the 23andMe Personal Genome Service. Also a good presentation by Linda… Continue reading The Sergey, Larry, Eric test by Anne & Linda: 23andMe at home
Gábor Zsurka, scientist and developer made another upgrade on our favorite human mitochondrial DNA visualization tool, MitoWheel: this time allele frequencies at polymorphic positions are included in the sequence bar in the form of a gray bar above or below a nucleotide representing the number of individuals carrying the SNP. This is really cool as… Continue reading Mitowheel now helps you design PCR primers for mitochondrial DNA!
Gábor Zsurka has built some killer functions into Mitowheel, the human mitochondrial DNA visualization tool: – compare GenBank‘s circa 3000 fully sequenced human mitochondrial genome to the revised Cambridge Reference Sequence mutation by mutation – by harnessing the power of the colorful group view and using the +, – mutation operators (see detailed introduction) you… Continue reading Mitowheel upgrade: phylogenetics in motion
The O’Reilly Emerging Technology Conference (ETech) is on and this year they had a growing number of biotech related sessions. Fellow SciFoo Campers like Hugh Rienhoff and Timo Hannay, Makers like Phil Torrone and Limor Fried, Brain Hackers like Ed Boyden are visiting and many more.
Esther Dyson‘s honest post on getting the genotype-health risk correlation statistics right on The Spittoon blog: What You Can Do for 23andMe (and Future Generations) To learn more, researchers need to collect thousands of genetic profiles – and the health data connected with each of them – to find correlations between the two. That leads… Continue reading The second goal of 23andMe: using customer’s real health data later
Your 16569 basepair long human mitochondrial genome does a lot for you and tells a lot about you. It encodes protein subunits playing crucial role in the production and conversion of ATP, the body’s main chemical energy currency. On the other hand the actual sequence of one’s mitochondrial DNA in a particular tissue or cell… Continue reading MitoWheel 1.0: the human mitochondrial genome just got visual!
When I had worked on my MSc thesis in biology on the relation of human mitochondrial mutations and aging the paper I used most frequently was Sequence and organization of the human mitochondrial genome by Anderson et al. published in Nature, 1981. The reason was simple: it is more of a database than a hypothesis… Continue reading The first human genome project: mitochondrial DNA, 16.6kb, 1981, Cambridge
In my former blog post inF.A.Q. for 23andMe: what if I have mitochondrial DNA from Pa? I meditated on 23andMe‘s capability of detecting paternal mitochondrial DNA in their customers’ saliva with their Illumina microarray chips scanning around 2000 mitochondrial single nucleotide variants. Published here the initial answer of the 23andMe Editorial Team to this fairly… Continue reading 23andMe on the biparental inheritance of mitochondrial DNA and more
23andMe is a biotech focused web startup based in Mountain View, California (yes, the Googleplex neighbourhood) self-defined as “an early stage startup developing tools and producing content to help people make sense of their genetic information. Our goal is to take advantage of new genotyping technologies and help consumers explore their genetics, informed by cutting… Continue reading 23andMe: the early bird of web based biotech startups
In order to introduce you the circular human mitochondrial DNA, I compare it shortly to its more famous neighbour, the chromosomal nuclear DNA. (Thx for Google Spreadsheets.)