Thesis live: 1.1 Turnover or Every cell has a lifespan

In the live thesis building blogxperiment I edit (digest, compile, write, rewrite, delete) my ongoing doctoral thesis in blog posts and put the parts together on thesis live. The title: The physiologic role of stem cells in tissues with different regenerative potential. 1.1 Stem cells and regenerative medicine: basic concepts /turnover: cellular turnover/ The concept…

2 models of embryonic and adult blood formation: Figure by Ueno and Weissman

If you have previously thought (in your spare time) that the conventional wisdom concerning blood formation is that the yolk sac’s embryonic blood-forming cells serve only the embryo, while the source of adult blood-forming stem cells is the region called aorta-gonad-mesonephros (AGM), it’s time to think it again due the elegant experiments of Samokhalov et…

First differentiated cell types in mammals are…

…blood cells, “generated in early-stage embryos, for instance in mice in the yolk sac at embryonic day (E) 7.0.-7.5, just 2 or 3 days after the undifferentiated conceptus implants in the uterus.” Source: Ueno-Weissman: Blood lines from embryo to adult Nature 446, 996-997 (26 April 2007)