1. DNA methylation age of human tissues and cell types by Steve Horvath: This is the type of relevant data mining study most bioinformaticians are dreaming of: you pull together a large body of publicly available datasets (CpG methylation) that are not too heterogeneous (Infinium type II assay on Illumina 27K or Illumina 450K array platform), derive robust… Continue reading Three links in Aging, Regenerative Medicine & Healthy Lifespan Extension: 17 December 2013
“for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase” press release The award goes to Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak. The problem of telomere/telomerases is highlighting the double but strictly related aging/cancer problem space: Blackburn Lab Greider Lab Szostak Lab
The Nobel Assembly at Karolinska Institute has today decided to award The Nobel Prize in Physiology or Medicine for 2007 jointly to Mario R. Capecchi, Martin J. Evans and Oliver Smithies for their discoveries of “principles for introducing specific gene modifications in mice by the use of embryonic stem cells” Link It’s rather a 2/3… Continue reading The first stem cell related Nobel prize: Martin Evans, 2007
It is now the 3rd issue of Cell Stem Cell, which is the official journal of the International Society for Stem Cell Research (ISSCR). From the current issue: In human pancreatic cancer a distinct subpopulation of migrating CD133+ CXCR4+ cancer stem cells turned out to be essential for tumor metastasis different from the ones responsible… Continue reading Biopolis profile and cancer stem cells in current Cell Stem Cell
In the lack of subscription to Stem Cells, I could not download the whole article or the subscription restricted supplemental data (at Stem Cells it seems people haven’t heard of free supplemental information) but this story is really interesting: Bone Marrow Contributes to Epithelial Cancers in Mice and Humans as Developmental Mimicry In brief: in… Continue reading Bone marrow stem cells, the great cancer pretenders?
You can now pre-order Ending Aging: The Rejuvenation Biotechnologies That Could Reverse Human Aging in Our Lifetime at Amazon written by Aubrey de Grey and Michael Rae which is the most detailed, although popular exposition of the SENS (Strategies for Engineered Negligible Senescence) plan to defeat aging. Aubrey was kind enough to mail me the… Continue reading Content of Ending Aging, Aubrey de Grey’s coming life extension book
According to the organizers the Edmonton Aging Symposium “was a WORLD FIRST! in being streamed live onto the internet.” Now you can download where possible, the video, powerpoint and audio MP3 recordings of the streaming split up by speaker in alphabetical order. I think this is really webhistorical and good news for all open access… Continue reading Edmonton Aging Symposium: full video, audio and presentation access
The trendy cancer stem cell theory highlights that there is a functional hierarchy between different tumour cells and only a small portion, the so called cancer stem cells have crucial role in initiating tumour growth. This assumption was confirmed in the case of blood, breast and brain for example. Based on that a new therapeutic… Continue reading Redifferentiating brain tumour stem cells: the concept of cancer regenerative medicine