I’ve been invited by Aubrey de Grey to give a talk on AgeCurve at the Undoing Aging Conference, this March, in Berlin. Here’s the bulk of the talk on YouTube:
In this new post series I utilise my philosophical training and formulate, collect and re-phrase arguments around what is aging and what is not. Since aging is conceptualised with the help or in the context of other heavyweight, loaded and complex concepts like health, disease, biomarkers, and last (but also first) time, those concepts will… Continue reading Aging, health, disease: more than philosophical arguments
1. DNA methylation age of human tissues and cell types by Steve Horvath: This is the type of relevant data mining study most bioinformaticians are dreaming of: you pull together a large body of publicly available datasets (CpG methylation) that are not too heterogeneous (Infinium type II assay on Illumina 27K or Illumina 450K array platform), derive robust… Continue reading Three links in Aging, Regenerative Medicine & Healthy Lifespan Extension: 17 December 2013
1. Is aging linear or does it follow a step function? A good & simple question on Quora that surprised even Aubrey de Grey. If you are a bioinformatician out there – looking for a new pet project – go pull together some data & try to plot it! Let me know if you have something.… Continue reading Three links in Aging, Regenerative Medicine & Healthy Lifespan Extension: 8 December 2013
Here’s an edited version of my Quora answer to the question: “Life Decisions: How do people who are talented in many areas decide what to do with their lives?“ Let me provide a personal story illuminating one option Ruchira is talking about: “pick a complex challenge that you are passionate about, that will require many different… Continue reading How to build a colorful life around life extension using different skills: a personal story
Kaiser Permanente alongside with UCSF plans for genetic analyses of an unprecedented 100,000 older Californians, the Technology Review writes in Massive Gene Database Planned in California The effort will make use of existing saliva samples taken from California patients, whose average age is 65. Their DNA will be analyzed for 700,000 genetic variations called single-nucleotide… Continue reading Aging-centric genetic health database in California: 100k people, ~65yrs, 700k SNPs, telomeres too
“for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase” press release The award goes to Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak. The problem of telomere/telomerases is highlighting the double but strictly related aging/cancer problem space: Blackburn Lab Greider Lab Szostak Lab
I had problems with my handwriting since elementary schools, or at least my teachers had continuous problems with it. Even during my university years I was asked sometimes to read out loud my essays, papers to them otherwise risking bad grades. Maybe it’s because I am a hidden right-handed using my left hand for writing… Continue reading Even ugly handwriting can fit the informal nature of SciFoo
Last year I was probably the only SciFoo Camper with an explicit life extension commitment. I suggested & held a session which was related a bit to partial immortalization but was rather about the systems biology perspective in general, illustrated with some examples. So throughout the terrific SciFoo Camp 2007 life extension as a conversation… Continue reading Life extension people & session at SciFoo 2008, Googleplex!
Finally Chris over at Ouroboros came up with the idea and the quick implementation of Hourglass, a blog carnival devoted to the biology of aging/biogerontology. For some reason I am not an explicit supporter of blog carnivals – many of my posts were chosen by carnival editors but I never hosted one -, but Hourglass… Continue reading Hourglass, a blog carnival devoted to the biology of aging
This is how my Macbook saw Aubrey de Grey’s talk exactly 1 week ago on the AGING preconference at UCLA.
Even tech people in Silicon Valley need to join their powerful forces and sources when it is about aging related neurodegenerative diseases and help research and the clinic. UCSF Memory and Aging Center channel on YouTube Om Malik: A Personal Note: Pause & Read via John Battelle
Just landed in my mailbox, emphasis added by me: Dear Attila, I would like to provide you with a copy of the press release to be distributed via press release distribution sites on Wednesday. We will also put it on our site within a few hours after this email so you can confirm its authenticity.… Continue reading The Biogerontology Research Foundation receives charitable status, UK
90 is the New 50: The Science of Longevity via Brandon Keim, Wired Science: Sunday, June 1, 7:00 PM – 8:30 PM,NYU – Kimmel Center for University Life Will it one day be possible to take a pill to stay young? How will an average life expectancy of beyond a hundred years affect society and… Continue reading The Science of Longevity at The World Science Festival, June 1, NYC
I found this picture of Aubrey de Grey with his book Ending Aging on his head at the BIL conference in Quinn Norton‘s Flickr Stream. Quinn Norton is a bodyhacker technophiliac journalist photographer. Robust, healthy lifespan extension can easily be interpreted as an extreme body-, life- and biohack so no wonder that more and more… Continue reading Life extension people are happy: keep living, please!
“The best way to predict the future is to invent it.” – said Alan Kay, computer legend in 1971. Recently I had a comment dialogue with Chris on whether state-supported research or industrial business enterprises can (or should) lead to big progress in robust and healthy life extension technologies. Besides the government and corporation coin… Continue reading Biotech DIY for aging/life extension research: the double future?
Huffington Post, Fortune’s Stanley Bing: The Next Big Thing? Please pay extra attention to the language here (especially transmogrification). Human genome schmutz: Nobody wants to get old or worse, appear old. And forget about dying. That’s the ultimate bummer. Genetic research has been held back recently by a series of disasters too terrible to mention… Continue reading Very well informed Stanley Bing on life extension
Looks like the scientist coalition behind healthy life extension is widening. In line with that the question Why was life extension ruled out of the 14 Grand Engineering Challenges? is fading away. Here is an Aubrey de Grey message from my mailbox: All details, including forms for abstract submission and online registration, are at the… Continue reading Understanding Aging Conference in L.A.: de Grey, Conboy, Wagers and many others…
The successful reprogramming (dedifferentiation) of differentiated human somatic cells into a pluripotent, embryonic stem cell-like state called induced pluripotent stem cells (iPS) using just 4 (and recently 3) introduced transcription factors is the biggest news of current stem cell biology. In the paper published in Cell by the Yamanaka group (Takahashi et al.) the iPS… Continue reading induced Pluripotent Stem cells from a 69 year old human: the hidden story?
Finally the Google PageRank algorithm, the core analysis tool of the current web is back to where its idea is originated from, scientific citation analysis. The recently launched SCImago Journal & Country Rank database uses an algorithm very similar to PageRank. It has a new metric: the SCImago Journal Rank (SJR). According to Nature: A… Continue reading Stat freaks, are you ready to play with the SCImago Journal & Country Rank?
Here is another sign that the editors at Science Magazine are taking more and more attention to the web and the scientific blogosphere: Ouroboros (that is: Chris, Okie and Lev) was picked up in the Random Samples column of the current Science issue: “But research on aging is booming, and the field’s good health is… Continue reading Science’s Netwatch: Aging blog in focus
Recently I wrote a meeting report on the SENS3 conference for a very prestigious science journal, but finally it did not go through the filters. I knew that the chance for publication is small as the journal rarely publish such meeting reports and as it was in many respects an unconventional science conference. The standards… Continue reading Unpublished SENS3 conference report for mainstream scientists!
My gmailbox says and I see no reason not to share it: The Open Aging Journal is an Open Access online journal, which publishes research articles, reviews and letters in all areas of aging science. The journal aims to provide the most complete and reliable source of information on current developments in the field. The… Continue reading The Open Aging Journal wants you to submit articles!
In order to slow the progress of aging and prevent age-related disease (which is not the same as figuring out a robust engineering plan for unlimited healthy life extension) biological measures (biomarkers) of aging or disease mechanisms are needed that anticipate clinical disease and are sensitive to functional organism aging. The American Federation for Aging… Continue reading Biomarkers of aging conference in New York City
Quick storytelling through citations (alert from Jim Hardy, thanks): Cell: Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival A major cause of cell death caused by genotoxic stress is thought to be due to the depletion of NAD+ from the nucleus and the cytoplasm. Here we show that NAD+ levels in mitochondria remain at physiological levels… Continue reading “Mitochondrial Oasis Effect”: fasting => NAD+ up in mitos => cell survival
For me, it was on SENS3, the presentation of Anun Hallen, who blamed only extracellular crosslinks (e.g. advanced glycation end products) for ageing. It was not the best presentation I’ve ever seen, I can tell ya. (I heard once, that there was a high school science contest in the 80’s with an overhead projector only… Continue reading The last time you saw a science presentation with an overhead projector
A supercentenarian is anyone with the chronological age of 110 years or older. Stephen Coles, M.D., Ph.D., co-founder of the Los Angeles Gerontology Research Group kindly sent me his slides of the presentation he held last week on SENS3 entitled the Secrets of the oldest old and he gave a permission to publish these slides… Continue reading SENS3: Stephen Coles on the secrets of supercentenarians (slides)
Embedded on the slideshow below 9 slides of Michael Rose‘s presentation called Slowing and then stopping aging on the SENS3 conference on the 9th of September. (Photos made by me with the iPhone.) Rose’s argument was: Aubrey de Grey’s original SENS proposal is based on the non-evolutionary assumption that aging is a process of accumulating… Continue reading Michael Rose, evolutionary SENS and aging as a loss of adaptation (slides)
says Steve Coles in his short presentation, Secrets of the oldest old. They found healthy sperms in the testis of a recently died 106 year old Californian.
The immortal strand hypothesis captures stem cell scientists’ imagination these days. According to Thomas Rando The immortal strand hypothesis posits that the propensity of stem cell compartments to give rise to cancer in later life can be minimized if stem cells, during the process of self-renewal, retain those DNA strands with the fewest mutations acquired… Continue reading SENS3 program: Mike Conboy on the immortal strand hypothesis
SENS3 is coming, so it’s time to take a closer look at the agenda. Here is my first pick: Friday 7th September, Session 6 14:20 John Schloendorn Tempe, USA Medical bioremediation J. Schloendorn, M. Hamalainen, S.K. Kemmish, L. Jiang, J. Rebo, B. Turner, B.E. Rittmann Center for Environmental Biotechnology, Biodesign Institute at Arizona State University,… Continue reading SENS3 program: John Schloendorn: Medical bioremediation
The Buck Institute in Novato, California is a rich private research center focusing on aging with the mission of “extending the healthy years of life”. They have a real interdisciplinary staff, exactly the one that is needed for studying aging, which is a notoriously multifactorial, multicausal, atypical and complex biological phenomenon. One of the faculty… Continue reading Ask a good scientist in a San Francisco Cafe: The Reality of Age Research
You can now pre-order Ending Aging: The Rejuvenation Biotechnologies That Could Reverse Human Aging in Our Lifetime at Amazon written by Aubrey de Grey and Michael Rae which is the most detailed, although popular exposition of the SENS (Strategies for Engineered Negligible Senescence) plan to defeat aging. Aubrey was kind enough to mail me the… Continue reading Content of Ending Aging, Aubrey de Grey’s coming life extension book
There is a formulation of the argument on why aging should be considered as an unnatural process by Atul Gawande in the current The Way We Age Now report in The New Yorker: “..scientists do not believe that our life spans are actually programmed into us. After all, for most of our hundred-thousand-year existence—all but… Continue reading Why aging is an unnatural process? An argument from Atul Gawande
According to the organizers the Edmonton Aging Symposium “was a WORLD FIRST! in being streamed live onto the internet.” Now you can download where possible, the video, powerpoint and audio MP3 recordings of the streaming split up by speaker in alphabetical order. I think this is really webhistorical and good news for all open access… Continue reading Edmonton Aging Symposium: full video, audio and presentation access
Following Reason’s links at Fight Aging here is a little conference webcasting from the Edmonton Aging Symposium. You also can read a Conference Report at Ouroboros. There was a Symposium Live Streaming where for the very nominal fee of $5 CAD per connection to cover bandwidth costs people could watch the majority of presentations in… Continue reading 3 Edmonton Aging (Life Extension) Symposium videos
The Edmonton Aging Symposium starts today. Based on the program and speakers you can expect hot debates: Huber Warner, Aubrey de Grey, Irina Conboy, Amit Patel, Judith Campisi. I hope that the discussions will be hot, clarifying, perspective and scale conscious (quantitative enough), backed by strict scientific arguments. The organizing principle of the sessions seems… Continue reading Edmonton Aging (Life Extension Technologies) Symposium starts, March 30-31.
The Coalition to Extend Life launched today an online petition to U.S. Congress and President in order to make the technological possibility of Indefinite Life Extension a national priority and public policy goal of the United States. They ask the power people to create the 4 main conditions that will make it possible. 1. a… Continue reading Unlimited Life Extension Petition to U.S. Congress and President: a good address?
Check out Grailsearch.org, which was started at the end of January and is hosted by software engineer Jim Craig with a deep interest in aging and bioinformatics. Grailsearch is a “community web portal intended for use by biogerontologists, students of biogerontology, software engineers, biochemists or anyone else interested in working towards the search for systems… Continue reading Grailsearch.org: aging information from a systems biology perspective
I think you would be in a serious trouble if I ask you to explain the concrete death of an old, but otherwise healthy man in terms of the suspected biological processes of human ageing, like slowly accumulating mitochondrial and chromosomal mutations, oxidative stress, overall cell loss, intra- or extracelular junk molecules or whatever. In… Continue reading Dying of old age: an unfounded myth? Rando paper, Box 2