Three links in Aging, Regenerative Medicine & Healthy Lifespan Extension: 24 November 2013

Introducing a new post format by reutilising Nat Torkington’s Four short links format over at O’Reilly Radar (thanks, Nat!).


1.  The Hallmarks of Aging: good review by European scientists trying to put some pieces next to each other (but not necessarily together). The 9 hallmarks are:

genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.

2. StemBook: good introductory material (broad and at times, deep), they even have a proteomics chapter.

an open access collection of invited, original, peer-reviewed chapters covering a range of topics related to stem cell biology written by top researchers in the field at the Harvard Stem Cell Institute and worldwide. Stem Book is aimed at stem cell and non-specialist researchers.

3. David Botstein, 71, on Joining Google’s Anti-Aging Play, Calico: a good initial seed of people are needed for this venture, looks like Botstein can think out of the box and does not want to hang on forever in academia.

Page, describing the new venture in a posting on Google Plus in September, said ”don’t be surprised if we invest in projects that seem strange or speculative compared with our existing Internet businesses.”

That’s what got Botstein. “I’m a basic scientist. I’m not a translational anything,” Botstein said. “I start with the opposite premise of the usual translational thinking. I start with the premise that we understand very little of the world. Specifically, we understand a tiny fraction of what’s written in our genomes. We understand a tiny fraction of what parts of medicine work well, and what parts are just tradition. We understand virtually nothing about the microbiome. The value of basic science, of course, is once we do understand something we might be able to do something.”

“We’re scientists, and we’re going to sit together and ask people their thoughts and we’re going to try to define areas that fit into this general but well-defined space, and focus on things that wouldn’t get done,” Botstein said.