Halcyon Molecular: whole genome sequencing well under $1000?

Halcyon Molecular is a quite ambitious startup,  don’t you think?

What we do:
Halcyon Molecular is developing an ultra-low-cost DNA sequencing technology. Our single molecule approach does not require PCR amplification and will allow for megabase read lengths with simultaneous determination of methylation pattern. We aim to sequence entire human genomes de novo for well under the “holy grail” cost-to-consumer of $1000.

3 thoughts on “Halcyon Molecular: whole genome sequencing well under $1000?

  1. Soft-updates guarantees that the only filesystem inconsistencies on unclean shutdown are leaked blocks and inodes. To resolve this you can run a background fsck or you can ignore it until you start to run out of space. We also could’ve written a mark and sweep garbage collector but never did. Ultimately, the bgfsck is too expensive and people did not like the uncertainty of not having run fsck. To resolve these issues, I have added a small journal to softupdates. However, I only have to journal block allocation and free, and inode link count changes since softdep guarantees the rest. My journal records are each only 32bytes which is incredibly compact compared to any other journaling solution. We still get the great concurrency and ability to ignore writes which have been canceled by new operations. But now we have recovery time that is around 2 seconds per megabyte of journal in-use. That’s 32,768 blocks allocated, files created, links added, etc. per megabyte of journal.

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