David Secko writes: “Today, it is thought that one third of the proteins present in a typical mammalian cell are covalently bound to phosphate (i.e. they are phosphorylated at one time or another)”
Well I haven’t checked what kind of measurement the above 1/3 estimation is based on but if true it is no wonder that phosphorylation is the almost constant subject of biological research. But if it is not true, then what’s the reason of the stardom?
I got one of my smartest comment to my Human proteome project: 21000 genes/1 protein, 10 years, $1 billion? from a scientist at the University if Rochester that could suggest an answer:
“Another example – we study protein phosphorylation and we think it’s important. Why? Because we can! We have methods and tools to measure it, but all along we have absolutely no evidence that phosphorylation is any more important than the hundred of other protein modifications that we know exist. There could be upwards of 1000 PTMs on every single protein, and we have the technology to accurately study about 5 of these.”