The first stem cell related Nobel prize: Martin Evans, 2007

martinevansThe Nobel Assembly at Karolinska Institute has today decided to award The Nobel Prize in Physiology or Medicine for 2007 jointly to Mario R. Capecchi, Martin J. Evans and Oliver Smithies for their discoveries of “principles for introducing specific gene modifications in mice by the use of embryonic stem cells” Link

It’s rather a 2/3 gene technology, 1/3 stem cell methodology Prize, but shows how those technologies are interrelated.

Evans is still an active scientist but here are 2 famous papers he authored or coauthored:

1. First teratocarcinoma paper (always those cancer cells), how to isolate and maintain them, Evans is the single author: The isolation and properties of a clonal tissue culture strain of pluripotent mouse teratoma cells. J Embryol Exp Morphol. 1972 Aug;28(1):163-76.

2. And then the switch to embryonic stem cells a decade later, a protocol lead to the 1998 Science paper by Thomson et al. on human ES cells: Evans, M. J. & Kaufman, M. H. Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-6. (1981).