Studies recommended for funding by California Stem Cell Rush dollars

The working future of embryonic stem cell biology and regenerative medicine is in the 38 projects listed and linked below. Or at least in some of them. These are the research projects that were recommended for funding available by the California Institute for Regenerative Medicine after a thorough evaluation and all applications can be found in the Public List of CIRM. 47 more were recommended for funding if money is available. If you choose to scan through the public abstracts of the proposal (linked with the numbers) I also strongly recommend to read the WEAKNESSES part of the review. The order of the projects is descending from the highest scientific score (out of 100) to the lowest.

96 Generation of forebrain neurons from human embryonic stem cells RS1-00205-1

95 The APOBEC3 Gene Family as Guardians of Genome Stability in Human Embryonic Stem Cells RS1-00210-1

95 Generation of hESC lines, under defined conditions, modeling normal & diseased states from material stored at the Burnham shared embryo bank. RS1-00305-1

94 Gene regulatory mechanisms that control spinal neuron differentiation from hES cells. RS1-00288-1

93 Mitochondrial Dysfunction in Embryonic Stem Cells RS1-00432-1

92 Transcriptional Regulation of Human Embryonic Stem Cells RS1-00434-1

92 Profiling surface glycans and glycoprotein expression of human embryonic stem cells RS1-00365-1

92 Cellular epigenetic diversity as a blueprint for defining the identity and functional potential of human embryonic stem cells RS1-00245-1

91 Analysis of Candidate Neural Crest Cells Derived from Human ES Cells RS1-00466-1

91 Human Embryonic Stem Cell Differentiation to Trophoblast: Basic Biology and Clinical Translation to Improve Human Fertility RS1-00207-1

91 Patient-specific cells with nuclear transfer RS1-00404-1

91 Role of Chromatin Modifiers in Regulating Human Embryonic Stem Cell Pluripotency RS1-00323-1

91 In Vivo Molecular Magnetic Resonance Imaging of Human Embryonic Stem Cells in Murine Model of Myocardial Infarction RS1-00326-1

91 Analysis of Candidate Neural Crest Cells Derived from Human ES Cells RS1-00466-1

91 MicroRNAs in Human Stem Cell Differentiation and Mental Disorders RS1-00462-1

91 Modeling Human Embryonic Development with Human Embryonic Stem Cells RS1-00259-1

90 Role of Mitochondria in Self-Renewal Versus Differentiation of Human Embryonic Stem Cells RS1-00313-1

90 Specification of Ventricular Myocyte and Pacemaker Lineages Utilizing Human Embryonic Stem Cells RS1-00198-1

90 Optimization of guidance response in human embryonic stem cell derived midbrain dopaminergic neurons in development and disease RS1-00271-1

90 Generation of long-term cultures of human hematopoietic multipotent progenitors from embryonic stem cells RS1-00280-1

90 Functions of RB family proteins in human embryonic stem cells RS1-00298-1

89 Derivation and Characterization of Cancer Stem Cells from Human ES Cells RS1-00228-1

88 Novel vectors for gene transfer into human ES cells RS1-00236-1

88 Programmed Cell Death Pathways Activated in Embryonic Stem Cells RS1-00163-1

88 Regulation of Specific Chromosomal Boundary Elements by CTCF Protein Complexes in Human Embryonic Stem Cells RS1-00195-1

88 Assessing the role of Eph/ephrin signaling in hESC growth and differentiation RS1-00199-1

88 Reprogramming Differentiated Human Cells to a Pluripotent State RS1-00319-1

88 Derivation and characterization of human ES cells from FSHD embryos RS1-00455-1

88 Self-renewal of human embryonic stem cells RS1-00327-1

87 Identifying small molecules that stimulate the differentiation of hESCs into dopamine-producing neurons RS1-00215-1

87 Differentiation of Human Embryonic Stem Cells to Intestinal Fates RS1-00243-1

86 MicroRNA Regulation of Human Embryonic Stem Cell Self-Renewal and Differentiation RS1-00161-1

86 Down-Regulation of Alloreactive Immune Responses to hES Cell-Derived Graft Tissues RS1-00402-1

85 Development of Neuro-Coupled Human Embryonic Stem Cell-Derived Cardiac Pacemaker Cells. RS1-00171-1

85 A method to maintain and propagate pluripotent human ES cells RS1-00174-1

85 In Vivo Imaging of Human Embryonic Stem Cell Derivatives and Tumorigenicity RS1-00322-1

85 Stem Cell Survival and Differentiation Through Chemical Genetics RS1-00289-1

85 Improving microenvironments to promote hematopoietic stem cell development from human embryonic stem cells RS1-00420-1

84 Role of the tumor suppressor gene, p16INK4a, in regulating stem cell phenotypes in embryonic stem cells and human epithelial cells. RS1-00444-1

The institutes’s oversight committee will decided which research moves forward and with how much money when it meets Feb. 15-16 in Burlingame. Link.

5 thoughts on “Studies recommended for funding by California Stem Cell Rush dollars

  1. PIMM is one of the few outlets that mentioned the SEED grant scores. Another was a venture capital site. See the “unexcited” item on californiastemcellreport.blogspot.com.

  2. Thank you, David. I am heavily interested in the research trends hidden in the projects. When science is on the agenda behind stem cells mainstream media tends to ignore first and usually reacts late.

  3. Ref the comment at the bottom of your document ‘The institutes’s oversight committee will decided which research moves forward and with how much money when it meets Feb. 15-16 in Burlingame’ are we able to view money awarded for each project? If so where can the details be found?

  4. Is it true that google knols are closing down in May? Just went to update my carp fishing articles and noticed a statemant that I have to transfer my fishing knols/articles to wordpress? help

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