New key protein player in mitochondrial fission and fusion: make or break

Regulators of the balance between mitochondrial fusion and fission events are of special interest. November 27, Journal of Cell Science: Katsuyoshi Mihara and colleagues identified a mammalian protein – mitofusin-binding protein (MIB) – that regulates mitochondrial fusion by interacting with mitofusins (Mfns), mitochondrial outer-membrane GTPases that are required for mitochondrial fusion. Overexpressed MIB induces mito fragmentation, silenced MIB by RNAi induces expansion of mitochondrial network fusion structures, inhibits cell growth. Link