Embedded is my classical style (no design, based on the figure section, Powerpoint instead of Keynote) Journal Club presentation on the following paper with the help of SlideShare: Alteration of Marrow Cell Gene Expression, Protein Production and Engraftment into Lung by Lung-derived Microvesicles: A Novel Mechanism for Phenotype Modulation by Aliotta JM, Sanchez-Guijo FM, Dooner GJ, Johnson KW, Dooner MS, Greer KA, Greer D, Pimentel J, Kolankiewicz LM, Puente N, Faradyan S, Ferland P, Bearer EL, Passero MA, Adedi M, Colvin GA, Quesenberry PJ. Stem Cells. 2007 Jul 2 Thanks for the permission, Jason Aliotta. After the abstract you can find some critical points we digged out during our journal club answered by the first author, Jason Aliotta himself.
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Abstract: Numerous animal studies have demonstrated that adult marrow-derived cells can contribute to the cellular component of the lung. Lung injury is a major variable in this process; however, the mechanism remains unknown. We hypothesize that injured lung is capable of inducing epigenetic modifications of marrow cells, influencing them to assume phenotypic characteristics of lung cells. We report that, under certain conditions, radiation injured lung induced expression of pulmonary epithelial cell-specific genes and prosurfactant B protein in cocultured whole bone marrow cells separated by a cell-impermeable membrane.
In brief: in women underwent male (Y chromosome tracked) bone marrow transplantation, different types of cancer were developed and the malignant tissue often contained small areas of male marrow cells. The same happened with BM transplanted mice with the same cancers. “When they viewed the cancerous tissues under the microscope, they found marrow cells shared outward features of the cancer cells.
“Our results indicate these cells act as developmental mimics; they come in and look like the surrounding neoplastic tissue but they aren’t actually the seed of cancer,” explains Dr. Christopher Cogle, first author the Stem Cells article. “At the worst, these cells could help support cancerous tissue by providing it with growth factors or proteins that help the cancer grow and survive. At the very least, these marrow cells are just being tricked into coming into the cancerous environment and then made to walk and talk like they don’t usually do.”
These results highlight the role of the local destination niche to the phenotype of the migrant and highly mobile bone marrow cells.
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