Comments on: The decellularized matrix hack: skipping many steps in tissue engineering http://pimm.wordpress.com/2008/07/08/the-decellularized-matrix-hack-skipping-many-steps-in-tissue-engineering/ A Biotech Geek (micro)Blogger's adventures through science, technology and the web... Thu, 17 Dec 2009 11:47:33 +0000 http://wordpress.com/ hourly 1 By: Mstudent http://pimm.wordpress.com/2008/07/08/the-decellularized-matrix-hack-skipping-many-steps-in-tissue-engineering/#comment-54877 Mstudent Sat, 20 Sep 2008 00:58:32 +0000 http://pimm.wordpress.com/?p=1619#comment-54877 Some days ago I read an article (in a press newsfeed, which arguably isn´t the best source for scientific details, but it´s the cheapest until I get back at university in two days) about a man in the UK who is going to try to perform transplants using genetically engineered pigs (six human genes, in theory) as a source. While I doubt that THAT experiment in particular will have much success (pig organs likely have a lot of antigens that will cause an hyperacute rejection reaction -and as a sidenote, I really hope he tries it with a loin first, because otherwise he might kill somebody-), I´m curious about whether a combination of the matrix hack and this would produce viable organs for transplant. Some days ago I read an article (in a press newsfeed, which arguably isn´t the best source for scientific details, but it´s the cheapest until I get back at university in two days) about a man in the UK who is going to try to perform transplants using genetically engineered pigs (six human genes, in theory) as a source. While I doubt that THAT experiment in particular will have much success (pig organs likely have a lot of antigens that will cause an hyperacute rejection reaction -and as a sidenote, I really hope he tries it with a loin first, because otherwise he might kill somebody-), I´m curious about whether a combination of the matrix hack and this would produce viable organs for transplant.

]]> By: Fernando http://pimm.wordpress.com/2008/07/08/the-decellularized-matrix-hack-skipping-many-steps-in-tissue-engineering/#comment-54720 Fernando Fri, 18 Jul 2008 18:20:02 +0000 http://pimm.wordpress.com/?p=1619#comment-54720 Dear Attilas, It is not "quite new in science" some people have been using this approach since 70's Please check the research of Dr. Stephen Badylak at the McGowan Institute for Regenerative Medicine, http://www.mirm.pitt.edu/badylak/ http://www.mirm.pitt.edu/people/bios/Badylak1.asp best, Fernando Dear Attilas,

It is not “quite new in science”
some people have been using this approach since 70’s

Please check the research of Dr. Stephen Badylak at the McGowan Institute for Regenerative Medicine,

http://www.mirm.pitt.edu/badylak/
http://www.mirm.pitt.edu/people/bios/Badylak1.asp

best,

Fernando

]]> By: Hourglass: A carnival of biogerontology « Ouroboros http://pimm.wordpress.com/2008/07/08/the-decellularized-matrix-hack-skipping-many-steps-in-tissue-engineering/#comment-54666 Hourglass: A carnival of biogerontology « Ouroboros Tue, 08 Jul 2008 18:38:50 +0000 http://pimm.wordpress.com/?p=1619#comment-54666 [...] According to Attila Csordás at Partial Immortalization, one solution would be to use the “decellularized matrix hack“: to chemically or enzymatically remove the cells from cadaver organs, and then regrow new [...] [...] According to Attila Csordás at Partial Immortalization, one solution would be to use the “decellularized matrix hack“: to chemically or enzymatically remove the cells from cadaver organs, and then regrow new [...]

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