10 themes of a stem cell biology comprehensive exam
Posted by attilacsordas on November 29, 2007
Stem cell biology – regenerative medicine
1. basic concepts: stem cell, kinds of stem cells (embryonic, placental, adult), uni-, multi-, pluripotency, stem cell markers, niche, regeneration, tissue engineering
2. embryonic derived stem cells
3. stem cells in between: placental derived stem cells
4. adult somatic stem cells
5. components of the stem cell niche
6. proposed regenerative mechanisms of stem cells: differentiation, fusion, the role of paracrine factors, immunomodulatory effects, anti-inflammatory effects…
7. stem cells of the skeletal muscle
8. stem cell therapies in muscle: heart, skeletal muscle
9. cancer stem cells
10. tissue engineering
6 Responses to “10 themes of a stem cell biology comprehensive exam”
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jrowley said
Hi Attila,
Thanks for the post the other day.
This looks like a pretty thorough top ten. Due to my strong bias, I would put more emphasis on the various Bone Marrow-derived cells, as well as adipose tissue (over skeletal muscle, at least for now). Under mechanism of action, I strongly believe (another bias) that general tissue repair is a fundamental action (breaking down scar, secretion of ECM/other components required to ‘build’ new tissue). Just a bias – that’s what blogs are for
Great list,
Jon
Ricardo said
Hey Attila, I just got my grade back from my Stem Cells class and it was pretty good. I loved the class but seem to have still SO much to learn.
What does number 5 represent. That is, is the niche considered the locations where such cells can be harvested?
I’d search for it, but I prefer to learn from the gurus
frodo441 said
what could be so ethically wrong with using the umbilical cord…or a womans’ ovary…ee’gads’ isn’t that for her to decide?…same old thing…
attila csordas said
Ricardo, 5: Elements of the stem cell niche: 2 figures by Scadden
Biomaterials as Therapies « The Regeneration Station said
[...] tissue regeneration, is still hotly debated – but it is likely a mixture of several actions (see item #6 in this post) that result from the cells producing multiple factors and releasing them into the local [...]
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