Michael Rose, evolutionary SENS and aging as a loss of adaptation (slides)
Posted by attilachordash on September 12, 2007
Embedded on the slideshow below 9 slides of Michael Rose’s presentation called Slowing and then stopping aging on the SENS3 conference on the 9th of September. (Photos made by me with the iPhone.) Rose’s argument was: Aubrey de Grey’s original SENS proposal is based on the non-evolutionary assumption that aging is a process of accumulating damage, while according to the evolutionary SENS version of Rose aging should be interpreted as a loss of adaption. The script is: breed mice with delayed reproduction over multiple generations (let evolution by natural selection give us the answer of how to build a long-lived animal), and then reverse engineer this answer to develop anti-aging therapies for genetically unaltered humans. The experimental basis of this proposal: Rose’s own ancient experiments with fruit flies (sorry, no reference yet, that’s what I’ve heard) showed that there is a plateau in mortality rates after many generations of breeded Drosophilas with delayed reproduction time which leads to the cessation of the aging process.
Does this method sound as one that gives us a complete engineering toolkit to achieve robust healthy life extension for early generations of humans under the reverse engineered treatment?
