The recent Carnival of Biotechnology is hosted on Babybiotechs and is rather industry and business oriented which is a good sign of a more mature industry. Check the posts and form an opinion.
Archive for March 27th, 2007
Carnival of Biotechnology on Babybiotechs
Posted by attilachordash on March 27, 2007
Posted in biotechnology, blog, business, industry | Leave a Comment »
How much do you think a scientific blog post is worth (in US dollars)?
Posted by attilachordash on March 27, 2007
Ok, this is the question I asked yesterday at LinkedIn Question&Answers service: How much do you think a scientific blogpost article of 300 words is worth (in US dollars)?
Posted in USA, blog, business, journalism, science blogs | 3 Comments »
Bone marrow cells and ejection fraction improvements in the human heart
Posted by attilachordash on March 27, 2007
The crucial question of every stem cell transplantation whether the cellular incorporation or other happenings (paracrine effects) results in any functional improvement. In heart it was showed that functional and metabolic regeneration of infarcted and chronically avital tissue can be achieved in humans using transplantation of bone-marrow-derived cells {Brehm and Strauer, 2006, Nat Clin Pract Cardiovasc Med, 3 Suppl 1, S101-4} {Nyolczas et al., 2007, Am Heart J, 153, 212.e1-7}. Ejection fraction (Ef) is the fraction of blood pumped out of a ventricle with each heart beat so it is an excellent physiologic parameter to measure with echocardiography.
In the case of patients with chronic myocardial infarction both global left ventricular ejection fraction (LVEF) and infarction wall-movement velocity were increased significantly (15% and 57%, respectively) after 3 months {Brehm and Strauer, 2006, Nat Clin Pract Cardiovasc Med, 3 Suppl 1, S101-4}. In the case of acute myocardial infarction, implanted autologous BMDCs both improved LVEF from (50 +/- 10% to 58 +/- 10% at 4-month follow-up in one study, and in another study the combined stem cell injection (intramyocardial and intracoronary) resulted in an increase in global EF, (from 34.8 to 39.5 percent), as well as a significant increase in wall motion at the six-month follow up {Schachinger et al., 2004, J Am Coll Cardiol, 44, 1690-9} {Nyolczas et al., 2007, Am Heart J, 153, 212.e1-7}
Figure: Left ventricular ejection fraction, measured by quantitative left ventricular angiography initially and at four-month follow-up for patients receiving bone marrow-derived progenitor cells (BMC). Bars represent mean ± SD. From Schachinger et al., 2004
Literature: Read the rest of this entry »
Posted in biology, heart, regenerative medicine, science, stem cells | Leave a Comment »
