Here is Chris’ answer to question 4, for me it was the most important because of its critical edge. Question 2 was about moderate or maximum life extension commitment and the question below is not restricted to maximum LE and unlimited lifespan but includes modest trials too.
4. What is the most probable technological draft of human life extension, which technology or discipline has the biggest chance to reach it earliest?(regenerative medicine, nanotechnology, gene therapy, caloric restriction, bionics, hormones, antioxidants, …)
In a hundred years, we won’t be able to look back and answer that question in a clear way. People who are committed to extending their lifespans will have taken multiple strategies. One can’t point to a life and say, these ten years were from exercise but these five were from resveratrol.
I think the first really useful technological life extension will have a very familiar form, e.g., “take this pill and call me in fifty years when you’re still alive.” Drugs that activate sirtuins and related pathways are very promising (I can’t spill the beans but I saw some amazing data at Cold Spring Harbor suggesting that there are already several working drugs). Once we’re better able to get our brains around calorie restriction, I think that CR mimetics will be right behind the sirtuin-based drugs. To the extent that these sorts of drugs will help prevent acknowledged illnesses like Type II diabetes, there’s already a clinical indication for them, so they should sail through approval on that basis. Read the rest of this entry »
